The study, published in the American Journal of Physiology-Gastrointestinal and Liver Physiology (2005, vol 288), investigated the effect of HCA on glucose response after a meal. Researchers in the Netherlands administered 310 milligrams/kilogram HCA or a control (no HCA) to rats before infusing glucose into their stomachs or intestines to imitate a meal.
Researchers found that the rats given HCA had a significantly delayed elevation in blood glucose following glucose administration, compared to the control rats. Furthermore, HCA delayed glucose elevation after both stomach and intestinal glucose infusion, excluding the possibility that HCA effected gastric emptying. The findings also suggest that the glucose uptake delay may help reduce the production of insulin.
“These data support a possible role for HCA as food supplement in lowering postprandial glucose profiles,” the study authors conclude. HCA supplementation may have therapeutic applications in the treatment of diabetes and obesity.
REFERENCES:
1. Wielinga PY et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005 Jun;288: G1144-G1149.
