Reports of herb-drug interactions are not uncommon. Because of the availability of herbal products over the counter, and the increasing number of individuals taking prescription medications, the interactions and sometimes-serious consequences are on the rise. One of the more common issues involving interactions is the changing levels of circulating drug in the body and the overwhelming need to adjust dosage.
A study from the University of Arkansas was published in May that examined herb drug interaction in relationship to the detoxification system in the liver that is responsible for breaking down and eliminating drugs from the body. Four commonly used herbs, Kava Kava, Black Cohosh, Goldenseal, and Valerian were all tested to assess their effects on the Cytochrome P450 enzyme system in the liver. The Cytochrome P450 enzyme pathways are responsible for the first steps in drug detoxification and elimination in the body.
The study found that Goldenseal decreased the activity of the enzyme system to the greatest degree, with Kava Kava in second and Black Cohosh in third with minimal effects. Valerian did not have any effect on the Cytochrome P450 enzyme system.
The results stress the seriousness of taking herbal supplements and the reasons why individuals who are taking prescription drugs need to talk with their physician before beginning any new treatment with a medication or herbal supplement.
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