Inflammation is associated with aging and many chronic diseases including heart disease and cancer. Inflammatory marker levels including C-reactive protein and cytokines (interleukin-6, IL-1 beta, and tumor necrosis factor) may be higher in older adults. Now research reports that age and chronic inflammation were the risk factors most commonly linked with mortality (death).
The study, published in the Journal of Gerontology: Medical Sciences, investigated risk factors associated with dying. A collaboration of American researchers analyzed the data of 5,888 American older adults participating in the Cardiovascular Health Study. The participants were followed for up to 16 years. Causes of death and risk factors such as age, weight, cardiovascular disease, cancer, dementia and inflammatory markers were analyzed.
The researchers found that other than age, high interleukin-6 levels was most commonly asociated with multiple causes of death. Interleukin-6 is an inflammatory cytokine (destructive cell-signaling chemical) that may cause or contribute to many disease states.
"The findings of the common risk factor interleukin-6 support the concept that there is an underlying age-related state of decline that is not disease specific," the study authors write. "The importance of inflammation, cognitive function, kidney, and lung function across causes suggests that these systems have less reserve, decline more strongly with age over time or with risk factor exposure, or simply that these systems have fewer mechanisms for adaptation or repair of injury than do other systems."
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Taking antioxidants can help prevent the damaging effects of free radicals (unstable molecules that cause damage to cells) and inflammation associated with degenerative diseases, cardiovascular disease and aging.
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