Many of our important bodily functions are regulated by an internal biological clock (or circadian rhythm). Our internal biological clock regulates our sleep cycle. The disruption of circadian rhythms have been linked with accelerated aging and age-related diseases. Now research reports that a regular sleep cycle combats aging and promotes youthfulness. Earlier death and health problems are linked to the biological clock regulating the sleep cycle.
The study, published in Aging, investigated the effects of disrupted biological clock on health and lifespan in the fruit fly (Drosophilia melanogaster). Researchers at Oregon State University in Corvallis administered short-term metabolic stress to normal fruit flies (control) and fruit flies without the gene regulating the sleep cycle.
The researchers found that the fruit flies without the gene lived as long as the normal flies unless they were subjected to stress. Middle-aged and older flies without sleep genes subjected to stress had shorter lifespans than the age-matched control flies. Findings also revealed that the older flies without genes had significantly more oxidative damage, functional decline and neuronal deterioration than the age-matched control flies.
“Together, these data suggest that impaired stress defense pathways may contribute to accelerated aging in the per mutant,” the study authors write. “In addition, we show that the expression of per gene declines in old wild type flies, suggesting that the circadian regulatory network becomes impaired with age.”
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