Dermal fibroblasts in skin cells play a major role in wound healing. Vitamin C is a well-known antioxidant that can help heal and protect the skin. Now research reports that vitamin C may protect the skin by promoting fibroblast production. These results may have important implications for protecting the skin against DNA damage.
The study, published in the journal Free Radical Biology and Medicine, investigated the effect of exposure to a vitamin C derivative, AA2P (ascorbic acid 2-phosphate) in cultured human skin cells (dermal fibroblasts). Researchers from the Department of Cancer Studies and Molecular Medicine at the University of Leicester, UK analyzed the genes that were activated by vitamin C .
The researchers found that vitamin C stimulated fibroblast proliferation in the wound area. Furthermore, the vitamin C treated fibroblasts had a faster repair of damaged DNA. This suggests that vitamin C can promote skin healing by increasing fibroblast wound repair and protecting against DNA damage.
“We propose that vitamin C may protect the skin by promoting fibroblast proliferation, migration, and replication-associated base excision repair of potentially mutagenic DNA lesions,” the study authors conclude.Â
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