Non alcoholic fatty liver disease (NASH) is most commonly caused by obesity. Fat that accumulates in liver cells can cause inflammation and oxidative stress (free radical cell damage). There is no approved treatment for NASH. Now research reports that vitamin E supplementation may slow the progression of NASH.
The double-blind, placebo-controlled trial, presented at the 60th Annual Meeting of the American Association for the Study of Liver Diseases, investigated the effects of vitamin E on NASH patients. Researchers at Virginia Commonwealth University administered daily either 800 IU vitamin E, 30 mg of the antidiabetic drug pioglitazone or a placebo to 247 nondiabetic NASH patients for six months. Liver biopsies were obtained on the participants at the end of the study.
The researchers found that 43 percent of the vitamin E group, 34 percent of the pioglitazone group and 19 percent of the placebo group had improved liver disease activity scores. Both the vitamin E and pioglitazone group had improved serum alanine aminotrasferase (liver injury biomarker) levels. The pioglitazone group had greater weight gain but improved insulin resistance.
“Not only did vitamin E improve liver function in 40% of the patients treated with it, but the specific type of vitamin E used in the study is inexpensive, readily available, and caused no side effects in patients who participated in the study,” says study author Arun Sanyal. MD., at Virginia Commonwealth University Department of Internal Medicine, in a news release.
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